CINCHONINE HYDROCHLORIDE
CINCHONINE HYDROCHLORIDE Basic information
- Product Name:
- CINCHONINE HYDROCHLORIDE
- Synonyms:
-
- Cinchonine monohydro
- (S)-Quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride
- cinchonine,monohydrochloride
- monohydrochloride,(9s)-cinchonan-9-o
- CINCHODININE DIHYDROCHLORIDE
- CINCHONINE HYDROCHLORIDE
- (+)-CINCHONINE HYDROCHLORIDE N-HYDRATE
- CINCHONINE HYDROCHLORIDE N-HYDRATE
- CAS:
- 5949-11-1
- MF:
- C19H23ClN2O
- MW:
- 330.85
- EINECS:
- 621-239-2
- Product Categories:
-
- Alkaloids
- Biochemistry
- for Resolution of Acids
- Optical Resolution
- Quinoline Alkaloids
- Quinolinecarboxylic Acids, etc.
- Quinolines
- Synthetic Organic Chemistry
- Mol File:
- 5949-11-1.mol
CINCHONINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 208-218 °C(lit.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- CAS DataBase Reference
- 5949-11-1
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 36/37-36-26
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- GD2962020
- F
- 8
- HazardClass
- 6.1(b)
- PackingGroup
- III
CINCHONINE HYDROCHLORIDE Usage And Synthesis
Description
Cinchonine hydrochloride not only possesses the required solubility and bioavailability criteria for pharmaceutical formulations while retaining desired therapeutic properties, but is also very stable in solution, which facilitates the preparation of aqueous formulations, especially injections.
Uses
Cinchonine hydrochloride can be used as an inhibitory substance for the phenomenon of "multidrug resistance" (MDR). In particular, cinchonine hydrochloride compositions are useful in the treatment of cancer-related diseases with MDR phenomena.
Biological Activity
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound in cinchona bark with antimalarial activity. It can activate endoplasmic reticulum stress to induce apoptosis in human hepatoma cells.
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CINCHONINE HYDROCHLORIDE(5949-11-1)Related Product Information
- CINCHONINE HYDROCHLORIDE N-HYDRATE,CINCHONINE HYDROCHLORIDE,(+)-CINCHONINE HYDROCHLORIDE N-HYDRATE
- Cinchonine
- QUININE FORMATE
- Quinidine
- CINCHONIDINE HYDROCHLORIDE
- QUININE HYDROBROMIDE
- QUININE BISULFATE HEPTAHYDRATE
- CINCHONINE SULFATE
- QUINIDINE GLUCONATE
- CINCHONIDINE HYDROCHLORIDE
- CINCHONIDINE SULFATE
- Quinine sulfate dihydrate
- QUININE GLUCONATE
- HYDROQUINIDINE HYDROCHLORIDE
- Cinchonidine
- CINCHONINE MONOHYDROCHLORIDE HYDRATE 9&
- CINCHONINE HYDROCHLORIDE N-HYDRATE,CINCHONINE HYDROCHLORIDE,(+)-CINCHONINE HYDROCHLORIDE N-HYDRATE
- L-CINCHONINE HYDROCHLORIDE