Amezinium methylsulfate Chemical Properties

Melting point:

176° (dec)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO : ≥ 34 mg/mL (108.51 mM)

form 

powder to crystal

color 

White to Light yellow

Merck 

14,394

CAS DataBase Reference

30578-37-1

Safety Information

RTECS 

UR6066500

HS Code 

2933.59.8000

Toxicity

LD50 in mice, rats (mg/kg): 1630, 1410 orally; 40.4, 45.5 i.v. (Teschendorf)

MSDS

• Language:English Provider:6-Methoxy-1-phenylpyridazin-1-ium-4-amine methylsulfate

Amezinium methylsulfate Usage And Synthesis

Originator

Regulton,Nordmark,W. Germany,1981

Definition

ChEBI: Amezinium metilsulfate is an azaheterocycle sulfate salt of amezinium. It is a sympathomimetic drug which suppresses noradrenaline reuptake and thereby elevating blood pressure. It is used for the treatment of low blood pressure in patients undergoing dialysis. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor, an antihypotensive agent, a sympathomimetic agent and an adrenergic uptake inhibitor. It contains an amezinium.

Manufacturing Process

18.7 parts of 1-phenyl-4-aminopyridazone-(6) and 19 parts of dimethyl sulfate in 400 parts of xylene are kept at 120°C for one hour while mixing well. The reaction mixture is suction filtered, 28 parts (89.5% of the theory) of 1-phenyl-4-amino-6-methoxypyridazinium methosulfate is obtained having a melting point of 173°C to 174°C after recrystallization from acetonitrile. The perchlorate has a melting point of 179°C to 182°C.

Therapeutic Function

Antihypotensive

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