CYCLO(-GLY-PRO) Chemical Properties

Melting point:

220-223℃

Boiling point:

447.9±34.0 °C(Predicted)

Density 

1.32

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO: >10mg/mL

form 

powder

pka

13.21±0.20(Predicted)

InChIKey

OWOHLURDBZHNGG-YFKPBYRVSA-N

Safety Information

WGK Germany 

3

CYCLO(-GLY-PRO) Usage And Synthesis

Chemical Properties

White crystal

Uses

Cyclo(-?Gly-?Pro) and its derivatives can be used as Cyclic Dipeptide Chitinase Inhibitors. It is also used to synthesize 5-HT1A receptor agonists.

Biological Activity

Cyclo-Gly-Pro is a neuro-protective compound, an endogenous diketopiperazine, which enhances memory. In the animal model of PD, the compound improved functional recovery when administered after the onset of dyskinesia. It appears th at the compound recovery function may result from non-proliferative neurogenesis th at results from the inhibition of apoptosis of stem cells and/or the promotion of neuronal-orientated proliferation in the SVZ (subventricular zone).

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