(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties

Boiling point:

295.2±40.0 °C(Predicted)

Density 

1.513±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

10.75±0.70(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933998090

(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER Usage And Synthesis

Uses

(5-BROMOPYRAZIN-2-YL) CARBAMIC ACID TERT-BUTYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

At 0 ??, to 5-bromopyrazine-2-amine (5736.8mg, 32.97mmol) in CH2Cl2 (80mL) solution was added 4-DMAP (403.2mg, 3.30mmol); then at 0 ?? drop two A solution of di-tert-butyl carbonate (11.4ml, 3.30mmol) in CH2Cl2; the mixture was stirred at room temperature; after the completion of the reaction was monitored by TLC, the solution was washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo; the crude product was chromatographed on a silica gel column Method, purified with ethyl acetate/petroleum ether (1/2) to obtain a white solid product (7250.4 mg, yield 80.2%).

(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER(914349-79-4)Related Product Information

• (5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER
• 5-BROMO-2-(METHYLAMINO)PYRAZINE
• 2-Amino-5-bromopyrazine