Benzofuran-2-boronic acid Chemical Properties

Melting point:

114-116 °C (lit.)

Boiling point:

340.4±34.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

6.22±0.30(Predicted)

form 

Powder

color 

Pale yellow to yellow

Water Solubility 

Soluble in water.

BRN 

1637889

InChI

InChI=1S/C8H7BO3/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H

InChIKey

PKRRNTJIHGOMRC-UHFFFAOYSA-N

SMILES

O1C(B(O)O)=CC2=CC=CC=C12

CAS DataBase Reference

98437-24-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36/37/39-36-37/39

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

IRRITANT, MOISTURE SENSITIVE

HS Code 

29310095

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Benzofuran-2-boronic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

It is used in the facile preparation of highly-functionalized, nitrogen-bearing diarylmethanes.

Uses

Benzofuran-2-boronic Acid is a reagent used in the facile preparation of highly-functionalized, nitrogen-bearing diarylmethanes.

Synthesis

2-Bromobenzofuran (5.0 mmol) was dissolved in dry 20 mL of tetrahydrofuran, and the mixture was cooled to -78 degrees C. n-Butyllithium (5.5 mmol, 2.43 M, 1.1 eq.) was then added slowly and dropwise to the mixture, and the reaction mixture was stirred for about 30 minutes before triisopropyl borate (10 mmol, 2.0 eq.) was added dropwise to the reaction system. The reaction mixture was then stirred for 30 minutes, allowed to warm up to zero degrees Celsius and stirred the reaction mixture at 0 degrees Celsius for 1 hour. At the end of the reaction, the reaction was quenched with 1 M hydrochloric acid (40 mL), then the reaction mixture was extracted with ethyl acetate (3 x 50 mL), the combined organic phases were dried over MgSO4 and filtered, and the filtrate was concentrated under reduced pressure to give the target product molecule benzofuran-2-boronic acid.

Benzofuran-2-boronic acid(98437-24-2)Related Product Information

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