L-KAWAIN Chemical Properties

Melting point:

142-148℃

alpha 

D20 +105° (abs alc)

Boiling point:

bp0.1 195-197°

Density 

1.1914 (rough estimate)

refractive index 

1.5557 (estimate)

storage temp. 

Amber Vial, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)

form 

Solid

color 

White to Light Yellow

Stability:

Light Sensitive

LogP

0.784 (est)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2932202000

L-KAWAIN Usage And Synthesis

Originator

Largon,Klinge

Uses

Kawain is a plant extract that shows antioxidant activity through cyclooxygenase enzyme inhibition. May also be active in tumor suppression and apoptotic induction.

Definition

ChEBI: Kawain is a member of 2-pyranones and an aromatic ether.

Manufacturing Process

To 1170 g ethyl acetoacetate at 100-110°C was added a little at time 1605 g bromosuccinimide. After cooling to the mixture was added 300 ml of carbon tetrachloride. From the mixture was isolated ethyl ester of bromoacetoacetic acid which was distilled at 105-125°C/18 mm; yield 67%.
By condensation of the mixture 1400 g ethyl ester of bromoacetoacetic acid, 700 g bromosuccineimide, 500 ml benzene and 350 mg zinc was prepared (R)-5,6-dihydro-4-methoxy-6-styryl-2H-pyran-2-one; melting point 157°C, yield 60-70%.

Therapeutic Function

Anesthetic; Tranquilizer

L-KAWAIN(500-64-1)Related Product Information

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