4-Biphenylacetic acid Chemical Properties

Melting point:

159-160 °C (lit.)

Boiling point:

312.08°C (rough estimate)

Density 

1.1035 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

2-8°C

solubility 

DMSO: soluble50mg/mL, clear, colorless to yellow

form 

Powder

pka

4.29±0.10(Predicted)

color 

Beige

Water Solubility 

39.27mg/L(25 ºC)

Merck 

14,3316

BRN 

1211592

InChI

InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)

InChIKey

QRZAKQDHEVVFRX-UHFFFAOYSA-N

SMILES

C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1

CAS DataBase Reference

5728-52-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xn

Risk Statements 

23/25-36/37/38-25-36/37/38/63-20/21/22

Safety Statements 

26-36/37/39-45-37/39-28A-26/36/3745/60-20-36

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

DU8229050

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29163900

Toxicity

LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)

MSDS

• Language:English Provider:4-Biphenylacetic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Biphenylacetic acid Usage And Synthesis

Description

Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.

Chemical Properties

Off-white powder

Originator

Lederle (USA)

Uses

Anti-inflammatory, analgesic drug.

Uses

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.

Definition

ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.

brand name

Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).

General Description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

4-Biphenylacetic acid(5728-52-9)Related Product Information

• Phenylacetic acid
• 4-Biphenylcarboxylic acid
• Xenyhexenic
• felbinacethyl
• cicloprofen
• xenbucin
• FLURBIPROFEN AXETIL
• (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID
• 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID
• FLURBIPROFEN SODIUM (200 MG)
• Namoxyrate
• butixirate
• (S)-Flurbiprofen
• 2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID
• 4-Biphenylacetic acid
• BIFEPROFEN
• 2',4'-difluorobiphenyl-4-acetic acid
• Fluprofen