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4-Biphenylacetic acid

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4-Biphenylacetic acid Basic information

Product Name:
4-Biphenylacetic acid
Synonyms:
  • 4-BIPHENYLACETICABID
  • Biphenyl-4-acetic acid 97%
  • 4-Biphenylacetic acid/Felbinac
  • 4 -BIPHENYLACETIC ACID 99% BP GRADE
  • 4-BIPHENYL ACETIC ACID 98.5%
  • 4-BIPHENYLACETIC ACID(METHOXYMETHYL)-1,1''-BIPHENYL
  • Napageln
  • 4-Biphenylacetic acid ,99%
CAS:
5728-52-9
MF:
C14H12O2
MW:
212.24
EINECS:
227-233-2
Product Categories:
  • Aromatics
  • Intermediates & Fine Chemicals
  • C13 to C42+
  • Carbonyl Compounds
  • Carboxylic Acids
  • Pharmaceuticals
  • Biphenyl derivatives
  • Biphenyl & Diphenyl ether
  • Organic acids
  • TRAXAM
Mol File:
5728-52-9.mol
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4-Biphenylacetic acid Chemical Properties

Melting point:
159-160 °C (lit.)
Boiling point:
312.08°C (rough estimate)
Density 
1.1035 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble50mg/mL, clear, colorless to yellow
form 
Powder
pka
4.29±0.10(Predicted)
color 
Beige
Water Solubility 
39.27mg/L(25 ºC)
Merck 
14,3316
BRN 
1211592
InChIKey
QRZAKQDHEVVFRX-UHFFFAOYSA-N
CAS DataBase Reference
5728-52-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T,Xn
Risk Statements 
23/25-36/37/38-25-36/37/38/63-20/21/22
Safety Statements 
26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DU8229050
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29163900
Toxicity
LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)

MSDS

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4-Biphenylacetic acid Usage And Synthesis

Description

Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.

Chemical Properties

Off-white powder

Originator

Lederle (USA)

Uses

Anti-inflammatory, analgesic drug.

Uses

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.

Definition

ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.

brand name

Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).

General Description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

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