Alantolactone Chemical Properties

Melting point:

78-79 C

Boiling point:

275 C

alpha 

D +175° (chloroform)

Density 

1.0610 (rough estimate)

refractive index 

1.4360 (estimate)

storage temp. 

-20°C

solubility 

DMSO: soluble15mg/mL (clear solution)

form 

powder

color 

white to beige

Odor

Peculiar sweet-minty, slightly woody odor

LogP

3.380

CAS DataBase Reference

546-43-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

26-36-36/37-24/25

WGK Germany 

3

HS Code 

29322090

MSDS

• Language:English Provider:Alantolactone

Alantolactone Usage And Synthesis

Description

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone-mix, used to detect sensitization to Compositae.

Chemical Properties

Crystalline powder

Uses

anthelmintic, antibacterial, antineoplastic

Uses

Alantolactone has been used:

• in cell viability assay
• to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
• in assessment of degranulation

Uses

Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer.

Definition

ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

Contact allergens

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone mix used to detect sensitization to Compositae-Asteraceae.

Solubility in organics

Soluble in alcohol and essential oils

storage

Store at -20°C

Alantolactone(546-43-0)Related Product Information

• ε-Caprolactone
• ETHANE
• Dimethyl sebacate
• Dimethyl sulfate
• Dimethyl ether
• Dimethyl fumarate
• CHLOROPHOSPHONAZO III
• Dimethyl carbonate
• N,N-Dimethylformamide
• Dacthal
• Hyaluronic acid
• Dimethyl sulfoxide
• Dimethyl sulfone
• Ethyl 2-(Chlorosulfonyl)acetate
• Dichlorodimethylsilane
• Dimethyl sulfide
• N,N-Dimethylacetamide
• Folic acid