ChemicalBook > Product Catalog > API > Circulatory system drugs > Antihypertensive drugs > L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Basic information
- Product Name:
- L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
- Synonyms:
-
- (S)-TIC
- (S)-N-tert-1,2,3,4-tetrahydroisoquinoline -3-carboxamide
- L-1,2,3,4-Tetrahydro
- 4-Tetrahydro-3-Isoquinolinecarboxylic acid
- [S]-1,2,3,4-Tetrahydro-3-Isoquinolingcarboxylic Acid
- (S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (for Quinapril)
- L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98%
- (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER
- CAS:
- 74163-81-8
- MF:
- C10H11NO2
- MW:
- 177.2
- EINECS:
- 616-058-0
- Product Categories:
-
- Carboxylic Acids
- (intermediate of quinapril)
- Amino Acids
- Carboxylic Acids
- Quinolines, Isoquinolines & Quinoxalines
- chiral
- IsoquinolinesPeptide Synthesis
- Chiral Building Blocks
- Heterocyclic Building Blocks
- Others
- Unnatural Amino Acid Derivatives
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Quinolines, Isoquinolines & Quinoxalines
- Peptide Synthesis
- a-amino
- Pharmaceuticals
- Halogenated Heterocycles ,Thiophenes ,Thiazolines/Thiazolidines
- Mol File:
- 74163-81-8.mol
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties
- Melting point:
- >300 °C(lit.)
- alpha
- -157.4 º (24 ºC)
- Boiling point:
- 309.12°C (rough estimate)
- Density
- 1.1607 (rough estimate)
- refractive index
- -166 ° (C=1, 1mol/L NaOH)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- soluble in Hot Water, Basic Water
- pka
- 2.21±0.20(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- optical activity
- [α]20/D 168°, c = 1.8 in 1.4 M NaOH
- BRN
- 4842199
- InChIKey
- BWKMGYQJPOAASG-VIFPVBQESA-N
- CAS DataBase Reference
- 74163-81-8(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HS Code
- 29334900
MSDS
- Language:English Provider:ACROS
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Usage And Synthesis
Description
(S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema.
Chemical Properties
white to light yellow crystal powde
Uses
(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate.
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acidSupplier
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel
- 021-61259108 18621169109
- market03@meryer.com
Shanghai HC Biotech Co., Ltd
- Tel
- 021-20227858
- sale@hcbiotech.com.cn
INTATRADE GmbH
- Tel
- +49 3493/605464
- sales@intatrade.de
Alfa Aesar
- Tel
- 400-6106006
- saleschina@alfa-asia.com
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid(74163-81-8)Related Product Information
- Tetrahydrofuran
- 1,2,3,4-Tetrahydroquinoline
- 1,2,3,4-TETRAHYDROISOQUINOLINE
- Tetramethylammonium hydroxide pentahydrate
- Isoquinoline
- Potassium hydrogen phthalate
- Isoquinoline-1-carboxylic acid
- 5,6,7,8-TETRAHYDROISOQUINOLINE
- cis-1,2,3,6-Tetrahydrophthalic anhydride
- 2-Tetrahydrofuroic acid
- H-TLE-OTBU HCL
- H-Tic-OMe·HCl
- L-tert-Leucine methyl ester hydrochloride
- H-Tic-OtBu·HCl
- (S)-6,7-Dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
- Quinapril hydrochloride
- Moexipril
- (S)-L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE,L-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BENZYL ESTER HYDROCHLORIDE