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ChemicalBook >  Product Catalog >  API >  Circulatory system drugs >  Antihypertensive drugs >  L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Basic information Description Safety Supplier Related

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Basic information

Product Name:
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Synonyms:
  • (S)-TIC
  • (S)-N-tert-1,2,3,4-tetrahydroisoquinoline -3-carboxamide
  • L-1,2,3,4-Tetrahydro
  • 4-Tetrahydro-3-Isoquinolinecarboxylic acid
  • [S]-1,2,3,4-Tetrahydro-3-Isoquinolingcarboxylic Acid
  • (S)-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid (for Quinapril)
  • L-1,2,3,4-Tetrahydroisoquinoline-3-CarboxylicAcid98%
  • (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYLESTHER
CAS:
74163-81-8
MF:
C10H11NO2
MW:
177.2
EINECS:
616-058-0
Product Categories:
  • Carboxylic Acids
  • (intermediate of quinapril)
  • Amino Acids
  • Carboxylic Acids
  • Quinolines, Isoquinolines & Quinoxalines
  • chiral
  • IsoquinolinesPeptide Synthesis
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Others
  • Unnatural Amino Acid Derivatives
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Quinolines, Isoquinolines & Quinoxalines
  • Peptide Synthesis
  • a-amino
  • Pharmaceuticals
  • Halogenated Heterocycles ,Thiophenes ,Thiazolines/Thiazolidines
Mol File:
74163-81-8.mol
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties

Melting point:
>300 °C(lit.)
alpha 
-157.4 º (24 ºC)
Boiling point:
309.12°C (rough estimate)
Density 
1.1607 (rough estimate)
refractive index 
-166 ° (C=1, 1mol/L NaOH)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
soluble in Hot Water, Basic Water
pka
2.21±0.20(Predicted)
form 
powder to crystal
color 
White to Almost white
optical activity
[α]20/D 168°, c = 1.8 in 1.4 M NaOH
BRN 
4842199
InChIKey
BWKMGYQJPOAASG-VIFPVBQESA-N
CAS DataBase Reference
74163-81-8(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HS Code 
29334900

MSDS

  • Language:English Provider:ACROS
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L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Usage And Synthesis

Description

(S)-(-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a quinoline derivative, which is used as an intermediate in the synthesis of quinapril. Quinapril, a product developed by Pfizer, was approved by the US FDA in 1991 for the treatment of hypertension, congestive heart failure and angioedema.

Chemical Properties

white to light yellow crystal powde

Uses

(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Quinapril EP Impurity A) is a Quinapril intermediate.

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