3-(2-Methylaminoethyl)indole Chemical Properties

Melting point:

87-89 °C(lit.)

Boiling point:

295.23°C (rough estimate)

Density 

0.9649 (rough estimate)

refractive index 

1.6210 (estimate)

storage temp. 

-20°C

solubility 

DMF: 11 mg/ml; DMSO: 5 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml; Methanol: 1 mg/ml

form 

Shiny Crystalline Powder or Flakes

pka

17.26±0.30(Predicted)

color 

White to off-white

InChI

InChI=1S/C11H14N2/c1-12-7-6-9-8-13-11-5-3-2-4-10(9)11/h2-5,8,12-13H,6-7H2,1H3

InChIKey

NCIKQJBVUNUXLW-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2)C(CCNC)=C1

CAS DataBase Reference

61-49-4(CAS DataBase Reference)

NIST Chemistry Reference

1H-Indole-3-ethanamine, N-methyl-(61-49-4)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

NM0450000

HS Code 

29339980

MSDS

• Language:English Provider:3-(2-Methylaminoethyl)indole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

3-(2-Methylaminoethyl)indole Usage And Synthesis

Chemical Properties

white to off-white shiny cryst. powder or flakes

Uses

Reactant for preparation of:• ;Manzamine analogues for the control of neuroinflammation and cerebral infections1• ;Serotonin 4 receptors (5-HT4) receptor agonists2• ;A sulful-containing indole alkaloid, glypetelotine3• ;Selective inhibitors of cyclin dependent kinase (CDK4)4• ;Antagonist of the human tachykinin NK-2 receptor5• ;Inhibitors of the tyrosine-specific protein kinase pp60c-src SH2 Domain6

Uses

N-Methyltryptamine (NMT) is a naturally-occurring tryptamine which may be derived from L-tryptophan or, indirectly, from serotonin. While substituted NMTs are psychoactive through their effects on monoamine action, NMT appears to be rapidly metabolized by monoamine oxidases. This product is intended for research and forensic applications.[Cayman Chemical]

Uses

N-Methyltryptamine is an alkylamine, a putative hallucinogen constituent from the root of Mimosa ophthalmocentra. An alkaloid from the leaves of Hammada scoparia.

Definition

ChEBI: N-methyltryptamine is a tryptamine alkaloid and a member of tryptamines. It has a role as a metabolite. It is functionally related to a tryptamine. It is a conjugate base of a N-methyltryptaminium.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 49, p. 87, 2001
Journal of Medicinal Chemistry, 19, p. 99, 1976 DOI: 10.1021/jm00223a016

3-(2-Methylaminoethyl)indole(61-49-4)Related Product Information

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