(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole Chemical Properties

Melting point:

111-116 °C

Boiling point:

498.9±28.0 °C(Predicted)

storage temp. 

-20°C

pka

4.44±0.70(Predicted)

optical activity

[α]22/D -57.0°, c = 1 in chloroform

InChI

InChI=1S/C25H26NOP/c1-25(2,3)23-18-27-24(26-23)21-16-10-11-17-22(21)28(19-12-6-4-7-13-19)20-14-8-5-9-15-20/h4-17,23H,18H2,1-3H3/t23-/m1/s1

InChIKey

DMOLTNKQLUAXPI-HSZRJFAPSA-N

SMILES

O1C[C@H](C(C)(C)C)N=C1C1=CC=CC=C1P(C1=CC=CC=C1)C1=CC=CC=C1

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29319090

(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole Usage And Synthesis

Uses

(S)-4-Tert-Butyl-2-(2-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole (cas# 148461-16-9) is a useful research chemical.

Chemical Properties

Colorless solid

Uses

(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline can be used as a ligand for enantioselective Heck reaction without any C=C double bond migration byproduct. It can also be used in a rhodium(I)-catalyzed enantioselective desymmetrization reaction of meso-3,5-dimethyl glutaric anhydride, to form substituted syn-deoxypolypropionate fragments in a single transformation.

General Description

The product is a phosphinooxazoline (PHOX) ligand introduced by Pfaltz and coworkers. These non-symmetrical modular P,N-ligands are particularly useful in cases where double bond migration leads to undesired products or mixtures of isomers.

(4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole(148461-16-9)Related Product Information

• tert-Butyl methyl ether
• Diphenyl-t-Butylsilanol
• (S)-4-benzyl-2-(quinolin-2-yl)-4,5-dihydrooxazole
• (4R)-4-(1,1-diMethylethyl)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-Oxazole