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(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

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(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid Basic information

Product Name:
(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid
Synonyms:
  • (3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid
  • (1R,3S,4S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid
  • (1R,3S,4S)-N-(Tert-butoxycarbonyl)-2-azabicyclo-[2.2.1]-heptane-3-carboxylic acid
  • (1R,3S,4S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid 97%
  • 2-Azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2-(1,1-diMethylethyl) ester, (1R,3S,4S)-
  • (1R,3S,4S)-3-[(2-methylpropoxy)carbonyl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid
  • Ledipasvir INT 2
  • Ledipasvir Impurity 14
CAS:
291775-59-2
MF:
C12H19NO4
MW:
241.28
EINECS:
808-164-2
Product Categories:
  • Pharmaceuticalintermediates
Mol File:
291775-59-2.mol
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(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid Chemical Properties

Melting point:
147-152 °C
Boiling point:
371.0±25.0 °C(Predicted)
Density 
1.232±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.05±0.20(Predicted)
optical activity
[α]22/D -170±10°, c = 1 in chloroform
InChIKey
IFAMSTPTNRJBRG-YIZRAAEISA-N
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Safety Information

Hazard Codes 
Xi,N
Risk Statements 
61-36/37/38
Safety Statements 
53-26-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
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(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid Usage And Synthesis

Uses

(1R,3S,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic Acid is a building block in the synthesis of Ledipasvir, a potent, once-??daily oral NS5A inhibitor for the treatment of Hepatitis C Virus infection. It is also used to prepare potent direct inhibitors of factor Xa which carries significant promise for developing effective and safe anticoagulants.

(3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acidSupplier

Suzhou Haiheng Biological Pharmaceutical Co., Ltd. Gold
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