N-BOC-3-Aminopiperidine Chemical Properties

Melting point:

181-182°C

Boiling point:

277.3±33.0 °C(Predicted)

Density 

1.02

refractive index 

1.4710-1.4750

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

clear liquid

pka

10.35±0.20(Predicted)

color 

Colorless to Light yellow

optical activity

Consistent with structure

Water Solubility 

Slightly soluble in water.

Sensitive 

Air Sensitive

InChI

InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3

InChIKey

AKQXKEBCONUWCL-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCCC(N)C1

CAS DataBase Reference

184637-48-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-51

Safety Statements 

26-39-37

HazardClass 

IRRITANT

HS Code 

29335990

N-BOC-3-Aminopiperidine Usage And Synthesis

Uses

3-Amino-1-Boc-piperidine is used as an organic chemical synthesis intermediate.

Synthesis

In a 200 mL four-necked flask equipped with a stirrer, pH sensor, and two dropping funnels, 90 g of ethanol and 10.0 g (0.1 mol) of 3-aminopiperidine were added and stirred at 10 to 15 °C. 21.8 g (0.1 mol) di-tert-butyl dicarbonate was slowly added through one dropping funnel while 17.6 g (0.11 mol) 25% aqueous sodium hydroxide was added dropwise through the other dropping funnel, and the dropping rate was controlled to maintain the pH of the reaction system between 11.8 and 12.2. The titration process was completed in about 1 hour. Upon completion of the reaction, the composition of the reaction mixture was analyzed and confirmed to contain 6% unreacted 3-aminopiperidine, 91.5% of the target product 3-amino-1-tert-butoxycarbonylpiperidine and 1.1% of the by-product 3-tert-butoxycarbonylaminopiperidine.

References

[1] Patent: EP1460061, 2004, A1. Location in patent: Page 6-7

N-BOC-3-Aminopiperidine(184637-48-7)Related Product Information

• 4-Amino-1-Boc-piperidine
• tert-Butanol
• Tris(trimethylsilyl)phosphate
• 6-Aminocaproic acid
• tert-Butyl peroxyacetate
• BUTYL OLEATE
• 3-Aminopyridine
• Glycine
• Diethylene glycol monobutyl ether
• 1-Aminopiperidine
• Butyl acetate
• Cyhalofop-butyl
• Haloperidol
• ALTRENOGEST
• Buprofezin
• Tris(hydroxymethyl)aminomethane
• N-BOC-1,2,3,6-TETRAHYDROPYRIDINE
• N-Boc-4-iodopiperidine