Formoterol fumarate dihydrate Chemical Properties

Melting point:

116-120°C

storage temp. 

2-8°C

solubility 

DMSO: soluble20mg/mL

form 

solid

color 

white to off-white

InChIKey

RATSWNOMCHFQGJ-XODSYJLDSA-N

SMILES

C(/C(=O)O)=C\C(=O)O.[C@@H](C1C=CC(O)=C(NC=O)C=1)(O)CN[C@@H](C)CC1C=CC(OC)=CC=1 |&1:8,22,r|

CAS DataBase Reference

183814-30-4

Safety Information

RIDADR 

UN 2811 6.1 / PGII

WGK Germany 

3

HS Code 

29242990

Formoterol fumarate dihydrate Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

Formoterol is a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.

Uses

ForMoterol FuMarate Dihydrate is a selective β2-adrenergic receptor agonist,it is used as an antiasthmatic.

Biological Activity

Potent, selective and long-acting β 2 -adrenoceptor agonist. Displays 330-fold selectivity for β 2 over β 1 receptors (pK d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD 2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.

Biochem/physiol Actions

β2-Adrenoreceptor agonist.

Drug interactions

The efficacy and tolerability of glycopyrronium/formoterol fumarate metered dose inhaler, a fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate 14.4/10 μg (equivalent to glycopyrrolate/formoterol fumarate 18/9.6 μg) delivered by metered dose inhaler using innovative co-suspension delivery technology, was investigated in patients (n = 292) with COPD [12C]. There were no meaningful pharmacokinetic interactions, whether drug–drug or due to formulation, between glycopyrronium and formoterol following treatment with formulated using a new co-suspension delivery technology. The incidence of cardiovascular events of special interest was low (stroke, 0%–0.4%; cardiac ischemia, 0.4%–2.3%; cardiac failure, 1.3%–2.5%; arrhythmia, 1.3%–3.2%), and no important trends in clinical laboratory results, vital signs, or electrocardiograms were observed[1].

References

[1] Aagaard, Lise . "A worldwide yearly survey of new data in adverse drug reactions." (2014).

Formoterol fumarate dihydrate(183814-30-4)Related Product Information

• CHLOROPHOSPHONAZO III
• Chlorantraniliprole
• 1-Hydroxyethylidene-1,1-diphosphonic acid
• Arformoterol tartrate
• Fumaric acid
• Dimethyl fumarate
• Formoterol
• Ketotifen fumarate
• Benzamide
• 4-Ethyl-5-fluoro-6-hydroxypyrimidine
• N,N-Dimethylformamide
• Formamide
• Ferrous fumarate
• Formoterol fumarate
• FOROXYMITHINE
• FUMARATE
• Formoterol fumarate dihydrate