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Formoterol fumarate dihydrate

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Formoterol fumarate dihydrate Basic information

Product Name:
Formoterol fumarate dihydrate
Synonyms:
  • Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, rel-, (2E)-2-butenedioate (2:1) (salt), dihydrate
  • Unii-W34shf8J2k
  • (±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamidehemifumarate
  • Formoterol fumarate dihydrate ,98.5%
  • (r*,r*)-n-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate dihydrate
  • Formoterol fumarate dihydrate
  • Formoterol Fumarate (100 mg)
  • forMaMide fuMarate dihydrate
CAS:
183814-30-4
MF:
C23H28N2O8
MW:
460.48
Product Categories:
  • Other APIs
  • API
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
183814-30-4.mol
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Formoterol fumarate dihydrate Chemical Properties

Melting point:
116-120°C
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL
form 
solid
color 
white to off-white
InChIKey
RATSWNOMCHFQGJ-XODSYJLDSA-N
SMILES
C(/C(=O)O)=C\C(=O)O.[C@@H](C1C=CC(O)=C(NC=O)C=1)(O)CN[C@@H](C)CC1C=CC(OC)=CC=1 |&1:8,22,r|
CAS DataBase Reference
183814-30-4
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Safety Information

RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
HS Code 
29242990
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Formoterol fumarate dihydrate Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

Formoterol is a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.

Uses

ForMoterol FuMarate Dihydrate is a selective β2-adrenergic receptor agonist,it is used as an antiasthmatic.

Biological Activity

Potent, selective and long-acting β 2 -adrenoceptor agonist. Displays 330-fold selectivity for β 2 over β 1 receptors (pK d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD 2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.

Biochem/physiol Actions

β2-Adrenoreceptor agonist.

Drug interactions

The efficacy and tolerability of glycopyrronium/formoterol fumarate metered dose inhaler, a fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate 14.4/10 μg (equivalent to glycopyrrolate/formoterol fumarate 18/9.6 μg) delivered by metered dose inhaler using innovative co-suspension delivery technology, was investigated in patients (n = 292) with COPD [12C]. There were no meaningful pharmacokinetic interactions, whether drug–drug or due to formulation, between glycopyrronium and formoterol following treatment with formulated using a new co-suspension delivery technology. The incidence of cardiovascular events of special interest was low (stroke, 0%–0.4%; cardiac ischemia, 0.4%–2.3%; cardiac failure, 1.3%–2.5%; arrhythmia, 1.3%–3.2%), and no important trends in clinical laboratory results, vital signs, or electrocardiograms were observed[1].

References

[1] Aagaard, Lise . "A worldwide yearly survey of new data in adverse drug reactions." (2014).

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