4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate CAS#: 85547-56-4

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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate

Basic information Safety Supplier Related

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Basic information

Product Name:

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate

Synonyms:

4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
PIPERAQUINE PHOSPHATE
Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate
antimalarial drugs PIPERAQUINE PHOSPHATE
2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP
Piperaquine PhosphateQ: What is Piperaquine Phosphate Q: What is the CAS Number of Piperaquine Phosphate Q: What is the storage condition of Piperaquine Phosphate Q: What are the applications of Piperaquine Phosphate

CAS:

85547-56-4

MF:

C29H32Cl2N6.H3PO4

MW:

633.51

EINECS:

1312995-182-4

Mol File:

85547-56-4.mol

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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Chemical Properties

storage temp.: Store at -20°C
solubility: DMSO: Insoluble;
form: Solid
color: Off-white to light yellow
Water Solubility: Water: 2 mg/mL (3.16 mM)
InChIKey: KATNPMSTHHZOTK-UHFFFAOYSA-N
SMILES: C(N1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1)CCN1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1.P(O)(O)(O)=O

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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Usage And Synthesis

Uses

Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

in vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice^[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t_1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice^[1].

Animal Model:	Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites^[1]
Dosage:	0, 10, 30, 90 mg/kg
Administration:	A single i.p. administration
Result:	The median survival time was 10 days at dose of 10 mg/kg. The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.

Animal Model:	Male Swiss mice (6 weeks old)^[1]
Dosage:	90 mg/kg (Pharmacokinetic Analysis)
Administration:	A single i.p. administration
Result:	t_1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.

References

[1] Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. DOI:10.1128/AAC.00878-07
[2] Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. DOI:10.2165/00003495-200565010-00004

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphateSupplier

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