2-(Trifluoromethyl)benzimidazole Chemical Properties

Melting point:

208-211 °C(lit.)

Boiling point:

262.8±40.0 °C(Predicted)

Density 

1.3658 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

pka

9.25±0.10(Predicted)

Appearance

Light brown to off-white Solid

Water Solubility 

PRACTICALLY INSOLUBLE

InChI

InChI=1S/C8H5F3N2/c9-8(10,11)7-12-5-3-1-2-4-6(5)13-7/h1-4H,(H,12,13)

InChIKey

MXFMPTXDHSDMTI-UHFFFAOYSA-N

SMILES

C1(C(F)(F)F)NC2=CC=CC=C2N=1

CAS DataBase Reference

312-73-2(CAS DataBase Reference)

NIST Chemistry Reference

2-Trifluoromethylbenzimidazole(312-73-2)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

23/24/25-36/37/38

Safety Statements 

22-26-36/37/39-45-28A

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

DE1576000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29332900

MSDS

• Language:English Provider:2-(Trifluoromethyl)-1H-benzo[d]imidazole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

2-(Trifluoromethyl)benzimidazole Usage And Synthesis

Chemical Properties

light grey fine powder

Uses

Agricultural chemical.

Hazard

A poison by ingestion.

Synthesis

O-phenylenediamine was dissolved in a 1:1 mixture of methanol and water, trifluoroacetic acid was added, and the reaction was carried out at 50?? for . 2 hours; after cooling to room temperature, concentrated under reduced pressure to remove methanol, the remaining aqueous phase was added to an aqueous sodium hydroxide solution, ethyl acetate was added to extract twice, the organic layers after extraction were combined, and the organic phases were washed with purified water, saturated saline, dried with anhydrous magnesium sulfate, pumped and filtered, spun-dried under reduced pressure to remove the organic solvent, and the residue was recrystallized with ethanol and water, to obtain the product 2-(trifluoromethyl)benzimidazole.

2-(Trifluoromethyl)benzimidazole(312-73-2)Related Product Information

• Imidazole
• 3-(Trifluoromethyl)benzaldehyde
• Benzo[b]thien-2-ylboronic acid
• 2-Chloromethylbenzimidazole
• 2-Phenylbenzimidazole
• 3-Aminobenzotrifluoride
• Benzimidazole
• 5-Nitrobenzimidazole
• 2-Methylbenzimidazole
• Trifluoromethanesulfonic acid
• 2-(Cyanomethyl)benzimidazole
• 2-(Trifluoromethyl)benzoic acid
• 2-GUANIDINOBENZIMIDAZOLE
• 5-Nitro-2-trifluoromethylbenzimidazole
• phenyl-5,6-dichloro-2-trifluoromethyl-benzimidazole-1-carboxylat
• 4-CHLORO-2-FLUORO-5-METHYLBENZENESULFONYL CHLORIDE
• 2-(3-HYDROXY-N-PROPYL)-5-(TRIFLUOROMETHYL)-BENZIMIDAZOLE
• (2-TRIFLUOROMETHYL-BENZOIMIDAZOL-1-YL)-ACETIC ACID