Chloromethyl isopropyl carbonate
Chloromethyl isopropyl carbonate Basic information
- Product Name:
- Chloromethyl isopropyl carbonate
- Synonyms:
-
- CMIC
- CHLOROMETHYL ISOPROPYL CARBONATE
- I-PROPYL CHLOROMETHYL CARBONATE
- Chloromethyl (1-Methylethyl) Carbonate
- Chloromethyl-2-propyl carbonate
- L-Propylchloromethylcarbonate
- Chloromethyl Isopropyl Carbonate (JMC-1)
- Carbonic acid, chloromethyl 1-methylethyl ester
- CAS:
- 35180-01-9
- MF:
- C5H9ClO3
- MW:
- 152.58
- EINECS:
- 1308068-626-2
- Product Categories:
-
- Miscellaneous Reagents
- Pharmaceutical Intermediates
- bc0001
- Mol File:
- 35180-01-9.mol
Chloromethyl isopropyl carbonate Chemical Properties
- Boiling point:
- 66 °C(Press: 16 Torr)
- Density
- 1.14
- refractive index
- 1.4110-1.4150
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO, Ethyl Acetate (Slightly)
- form
- clear liquid
- color
- Colorless to Almost colorless
- Stability:
- Moisture sensitive
- InChI
- InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3
- InChIKey
- JHYNXXBAHWPABC-UHFFFAOYSA-N
- SMILES
- C(OC(C)C)(=O)OCCl
- CAS DataBase Reference
- 35180-01-9(CAS DataBase Reference)
Safety Information
- Safety Statements
- 24/25
- RIDADR
- 2924
- HazardClass
- 3/8
- PackingGroup
- Ⅲ
- HS Code
- 29189900
Chloromethyl isopropyl carbonate Usage And Synthesis
Chemical Properties
Clear Colourless Liquid
Uses
Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
Synthesis
At 0-5°C, a photoinitiator is added, and dimethyl carbonate and chlorine are subjected to light reaction. The reaction is stopped, and the product is distilled and separated to obtain dimethyl monochlorocarbonate. At 70-100°C, a catalyst is added, and dimethyl monochlorocarbonate and isopropanol are added to a distillation tower capable of controlling the reflux ratio. Methanol is distilled and separated under normal pressure while reacting. After the reaction is completed, excess isopropanol is distilled off under reduced pressure, and finally chloromethyl isopropyl carbonate is distilled under reduced pressure.
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Chloromethyl isopropyl carbonate(35180-01-9)Related Product Information
- Chloromethyl ethyl carbonate
- Diethyl (tosyloxy)methylphosphonate
- Tenofovir
- Fluorobenzene
- Sodium metabisulfite
- Quinolinic acid
- Chloromethyl chlorosulfate
- Chloromethyl isobutyrate
- (S)-Metolachlor
- N2-ISOBUTYRYL-2'-DEOXYGUANOSINE
- 2-Hydroxypropyl methacrylate
- Propylene carbonate
- Allyl methacrylate
- Isopropyl chloroformate
- Diisopropyl peroxydicarbonate
- Triphosgene
- rac-Tenofovir-d7
- ChloroMethyl Propyl Carbonate