PP3 Chemical Properties

Melting point:

214-217 °C

storage temp. 

-20°C

solubility 

DMF, DMSO, Hot methanol

form 

Off-white solid

color 

Whit to Off-White

λmax

240nm(H2O (pH 1))(lit.)

BRN 

198460

CAS DataBase Reference

5334-30-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-22

Safety Statements 

36/37/39-26

Hazard Note 

Irritant

HS Code 

29335995

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

PP3 Usage And Synthesis

Chemical Properties

Whit to Off-White Solid

Uses

Intermediate in the preparation of various enzymatic inhibitors

Uses

The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. Several small molecule inhibitors of this signaling pathway have been developed as a therapeuptic strategy to abate abnormal Src kinase activity. PP3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2 . At concentrations as high as 10 μM, it does not prevent proliferation mediated by a stem cell factor/mast cell growth factor in hematopoietic and cancer cell lines.[Cayman Chemical]

Definition

ChEBI: 1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine is a ring assembly and a member of pyrazoles.

Biological Activity

Negative control for the src kinase inhibitor PP 2 (3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine ). Inhibits EGFR kinase (IC 50 = 2.7 μ M).

storage

-20°C

PP3(5334-30-5)Related Product Information

• PP3
• 1-PHENYLPYRAZOLE
• (1-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL)-HYDRAZINE
• NSC4912
• BUTTPARK 59\40-21
• BUTTPARK 56\40-48
• BUTTPARK 127\40-10
• BUTTPARK 141\40-58
• BUTTPARK 141\40-57
• BUTTPARK 127\40-15
• 4-[4-(4-METHYLPHENYL)PIPERAZIN-1-YL]-1-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE
• BUTTPARK 127\40-02
• BUTTPARK 127\40-12
• BUTTPARK 127\40-09
• BUTTPARK 127\40-07
• BUTTPARK 127\40-11
• BUTTPARK 127\40-08
• BUTTPARK 126\40-99