(10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione Chemical Properties

Melting point:

110-115 °C

Boiling point:

692.207±55.00 °C(Press: 760.00 Torr)(predicted)

Density 

1.219±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

form 

Solid

pka

12.779±0.70(predicted)

color 

White to off-white

(10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione Usage And Synthesis

Uses

Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity[1].

Definition

ChEBI: 23,24-dihydrocucurbitacin B is a 23,24-dihydrocucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at position 5; a hydroxy function at C-25 is acetylated. It is a 23,24-dihydrocucurbitacin, a secondary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It is functionally related to a cucurbitacin B.

References

[1] Escandell JM, et al. Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation. J Pharmacol Exp Ther. 2007 Sep;322(3):1261-8. DOI:10.1124/jpet.107.122671

(10α)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9β-methyl-19-norlanost-5-ene-3,11,22-trione(13201-14-4)Related Product Information

• CPNQ
• Bromothymol Blue
• cucurbitacins
• arvenin I
• CUCURBITACIN I
• Cucurbitacin A
• 3-epi-isocucurbitacin B
• colocynthin
• Cucurbitacin E
• CUCURBITACIN D
• Cucurbitacin C
• CUCURBITACIN B