5-Amino-2,3-dichloropyridine Chemical Properties

Melting point:

107-112 °C

Boiling point:

321.3±37.0 °C(Predicted)

Density 

1.497±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

0.88±0.10(Predicted)

form 

powder to crystal

color 

White to Light yellow to Light orange

InChIKey

XTCHZNJJTQACES-UHFFFAOYSA-N

CAS DataBase Reference

98121-41-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-41-37/38-25

Safety Statements 

26-36/37-36-45-39

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29333999

5-Amino-2,3-dichloropyridine Usage And Synthesis

Chemical Properties

Light yellow powder

Uses

5-Amino-2,3-dichloropyridine is a useful research reagent for organic synthesis.

Synthesis

Example 10 Synthesis of 5-amino-2,3-dichloropyridine: 77.2 g (0.4 mol) of 2,3-dichloro-5-nitropyridine was dissolved in 135 mL of glacial acetic acid and 800 mL of water was slowly added under stirring conditions. Subsequently, 111.7 g (2 mol) of iron powder was added in batches, and the reaction temperature was controlled not to exceed 50 °C. After completion of the reaction, the mixture was filtered and the filtrate was extracted using ethyl acetate. The extracted organic phase was washed with water to neutral and subsequently dried with anhydrous magnesium sulfate and concentrated by rotary evaporator. The final product was purified by recrystallization from toluene to obtain 85% yield with a melting point of 107 °C.

References

[1] Patent: US4756739, 1988, A
[2] Patent: US5922732, 1999, A

5-Amino-2,3-dichloropyridine(98121-41-6)Related Product Information

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