3-BROMO-2-HYDROXY-5-METHYLPYRIDINE Chemical Properties

Melting point:

78-82 °C (lit.)

Boiling point:

324.0±42.0 °C(Predicted)

Density 

1.622±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

10.95±0.10(Predicted)

form 

powder to crystal

color 

White to Orange to Green

BRN 

1423374

CAS DataBase Reference

17282-02-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-36/37/38

Safety Statements 

26-36/37/39-36

RIDADR 

1993

WGK Germany 

3

Hazard Note 

Irritant/Keep Cold

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-BROMO-2-HYDROXY-5-METHYLPYRIDINE Usage And Synthesis

Chemical Properties

White solid

Synthesis

5-Methylpyridin-2-ol (1 g, 9.16 mmol) was used as starting material and dissolved in 4 mL of carbon disulfide (CS2). Bromine (Br2, 0.47 mL) was slowly added to this solution at room temperature and the reaction mixture was stirred for 2 hours. Upon completion of the reaction, aqueous sodium thiosulfate (Na2S2O3) was added to quench the reaction, followed by extraction of the reaction mixture with ethyl acetate (EtOAc). The organic layer was separated, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to afford the solid product 3-bromo-2-hydroxy-5-methylpyridine (1.7 g, 98% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 7.73 (1H, s), 7.22 (1H, s), 2.10 (3H, s).

References

[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0168
[2] Patent: US2008/85906, 2008, A1. Location in patent: Page/Page column 15

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