2-Methylpiperidine Chemical Properties

Melting point:

-4--5 °C

Boiling point:

118-119 °C/753 mmHg (lit.)

Density 

0.844 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.446(lit.)

FEMA 

4244 | 2-METHYLPIPERIDINE

Flash point:

47 °F

storage temp. 

Flammables area

form 

Liquid

pka

pK1:10.95(+1) (25°C)

color 

Clear yellow

PH

12-13 (111g/l, H2O)

Odor

at 1.00 % in propylene glycol. amine fishy seafood taco corn chip

Odor Type

ammoniacal

Water Solubility 

soluble

JECFA Number

1608

BRN 

79804

LogP

1.42

CAS DataBase Reference

109-05-7(CAS DataBase Reference)

NIST Chemistry Reference

2-Methylpiperidine(109-05-7)

EPA Substance Registry System

Piperidine, 2-methyl- (109-05-7)

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

11-36/37/38-34-22-41-37/38

Safety Statements 

16-26-39-45-36/37/39

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

RTECS 

TN1240000

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29333999

MSDS

• Language:English Provider:2-Pipecoline
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Methylpiperidine Usage And Synthesis

Chemical Properties

Colorless to yellow liquid; pepper-like aroma.

Uses

2-Methylpiperidine, is used for the oxidation of secondary amines to nitrones by means of H2O2 catalyzed by Sodium tungsten oxide dihydrate.

Uses

Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation
Reactant for synthesis of:
Azepan-4-ones via two step [5+2] annulation
2-Aminobenzoxazoles
Unsymmetrically substituted ureas
Corticotropin-releasing factor receptor type 1 antagonists
Gefitinib analogues with anti-tumor activity

Definition

ChEBI: 2-Methylpiperidine is a member of piperidines.

Aroma threshold values

High strength; ammoniacal type; recommend smelling in a 1.0% solution or less.

Taste threshold values

Amine, creamy, taco, lettuce taste at 5 ppm in water.

Synthesis Reference(s)

Journal of the American Chemical Society, 111, p. 4108, 1989 DOI: 10.1021/ja00193a056

2-Methylpiperidine(109-05-7)Related Product Information

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• 5-Bromo-2-methylpyridine
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• DROPERIDOL
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• Dimethyl sulfoxide
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• 2-Picoline-N-oxide
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• Tiglic aldehyde
• Tropine
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