4-(3-Chloropropyl)morpholine Chemical Properties

Melting point:

NA

Boiling point:

115°C/25mmHg(lit.)

Density 

1.0409 g/cm3

RTECS 

QE0488000

refractive index 

1.4720-1.4760

Flash point:

91 °C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

pka

7.03±0.10(Predicted)

Specific Gravity

1.08

color 

Colourless to Yellow

InChI

InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2

InChIKey

PQECODMSWJOUAT-UHFFFAOYSA-N

SMILES

N1(CCCCl)CCOCC1

CAS DataBase Reference

7357-67-7(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2934999090

4-(3-Chloropropyl)morpholine Usage And Synthesis

Description

4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes.

Chemical Properties

Pale Yellow Oil

Uses

Gefitinib intermediate.

Application

4-(3-Chloropropyl)morpholine is an organic synthetic reagent or pharmaceutical intermediate used in the synthesis of gefitinib. It has cancer-inhibiting properties and inhibits epidermal growth factor (EGF). It also inhibits cell proliferation by inhibiting DNA synthesis.

4-(3-Chloropropyl)morpholine(7357-67-7)Related Product Information

• Moroxydine
• Morpholine
• N-Formylmorpholine
• 4-Methylmorpholine
• Moroxydine hydrochloride
• 3-Chloropropyltrichlorosilane
• Dimethomorph
• Chloromethyl isopropyl carbonate
• Allyl chloride
• Propylthiouracil
• 3-Chloropropyltriethoxysilane
• N-Isopropylacrylamide
• POLY(N-ISOPROPYL ACRYLAMIDE)
• N-(3-Aminopropyl)morpholine
• 4-Chloro-3-fluoronitrobenzene
• Isovanillin
• Benzonitrile, 5-methoxy-4-[3-(4-morpholinyl)propoxy]-2-nitro-
• 4-Chloro-3-fluoroaniline