TRISIALOGANGLIOSIDE GT1B 3NA Chemical Properties

storage temp. 

−20°C

solubility 

DMSO: soluble

form 

lyophilized powder

color 

Off-White

Safety Information

WGK Germany 

3

HS Code 

29400090

MSDS

• Language:English Provider:SigmaAldrich

TRISIALOGANGLIOSIDE GT1B 3NA Usage And Synthesis

Chemical Properties

lyophilized powder

Uses

Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cellular signaling events. Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. Ganglioside GT1b has inhibitory effects towards human humoral immune responses. At 0.1-10 μM, it can inhibit spontaneous IgG, IgM, and IgA production by human peripheral blood mononuclear cells. It has also been proposed as a host cell receptor for the Merkel cell polyomavirus and as a means to enable the initiation of an infection leading to Merkel cell carcinoma.[Cayman Chemical]

Uses

Ganglioside GT1b trisodium salt (bovine brain) is a glycosphingolipid neuroprotectant.

General Description

Ganglioside GT1b is a brain ganglioside. It is composed of a neutral tetra-saccharide core, with one or two sialic acid on the internal galactose and an extra sialic acid on the non-reducing terminal of galactose.

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