KM 11060
KM 11060 Basic information
- Product Name:
- KM 11060
- Synonyms:
-
- 7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE
- 7-CHLORO-4-[4-[4-CHLOROPHENYL)SULFONYL]-1-PIPERAZINYL]QUINOLINE
- KM 11060
- CFTR-F508del Corrector, KM11060
- KM11060;KM-11060
- Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-
- KM 11060,inhibit,KM11060,Inhibitor,Autophagy,Cystic fibrosis transmembrane conductance regulator,CFTR,KM-11060
- CAS:
- 774549-97-2
- MF:
- C19H17Cl2N3O2S
- MW:
- 422.33
- Mol File:
- 774549-97-2.mol
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KM 11060 Chemical Properties
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO and to 10 mM in ethanol
- form
- Powder
- color
- White to off-white
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KM 11060 Usage And Synthesis
Uses
KM 11060 is a small molecular corrector of F508del CFTR trafficking, which has potential application in cystic fibrosis therapeutics.
Biological Activity
Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
KM 11060Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
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KM 11060(774549-97-2)Related Product Information
- TPP
- Benzyl alcohol
- 4-Chloroaniline
- Sulfenone
- 4'-Hydroxyacetophenone
- Chlorobenzene
- 7-CHLORO-4-N,N-DIMETHYLAMINO-QUINOLINE
- 1-(4-Pyridyl)piperazine
- 4-(2-AMINOETHYLAMINO)-PYRIDINE HYDROCHLORIDE
- KM 11060
- 7-Chloro-4-piperazinoquinoline
- 4-(2-AMINOETHYL)AMINOQUINOLINE
- 7-CHLORO-4-(4-[(4-CHLORO-3-NITROPHENYL)SULFONYL]PIPERAZINO)QUINOLINE
- 4-(2-AMINOETHYL)AMINO-7-CHLOROQUINOLINE
- 4-PIPERAZIN-1-YL-QUINOLINE
- 1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE