Serotonin hydrochloride Chemical Properties

Melting point:

149-154 °C(lit.)

storage temp. 

2-8°C

solubility 

H₂O: 17 mg/mL

form 

powder

color 

white to off-white

Water Solubility 

soluble

Sensitive 

Light Sensitive & Hygroscopic

Merck 

14,8462

BRN 

3570963

Stability:

Stable, but light sensitive and hygroscopic. Incompatible with strong oxidizing agents.

InChIKey

MDIGAZPGKJFIAH-UHFFFAOYSA-N

CAS DataBase Reference

153-98-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi,Hazard

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-26-36

RIDADR 

UN2811

WGK Germany 

3

RTECS 

NM2571000

F 

3-8-10

HazardClass 

6.1

PackingGroup 

III

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Serotonin hydrochloride Usage And Synthesis

Chemical Properties

white to cream powder

Uses

Neurotransmitter;5-HT agonist

Uses

Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract. Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low levels of serotonin are associated with several disorders, including depression, migraines, bipolar disorder, and anxiety. Its actions are terminated primarily via uptake of serotonin from the synapse. Serotonin reuptake can be inhibited with MDMA, cocaine, tricyclic antidepressants, and selective serotonin reuptake inhibitors.[Cayman Chemical]

Uses

Serotonin hydrochloride is used as a neurotransmitter and function as an endogenous serotonin receptor agonist in various biochemical processes. It is an active component, which is used to regulate the mood, emesis, cognition and appetite in vivo.

Uses

A neurotransmitter.

Uses

Serotonin is a monoamine neurotransmitter.

Definition

ChEBI: Serotonin hydrochloride is a member of tryptamines. It is functionally related to a serotonin.

Biological Activity

Endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo .

Biochem/physiol Actions

Neurotransmitter.

storage

Store at -20°C

Purification Methods

5-HT is purified by recrystallisation from EtOH/Et2O or Et2O to give the hygroscopic salt. Store it in the dark as it is light sensitive. The free base has m 84-86o (from Et2O). The 5-benzyloxy derivative has m 84-86o (from Et2O). [Ek & Witkop J Am Chem Soc 76 5579 1954, Hamlin & Fischer J Am Chem Soc 73 5007 1951.] The picrate 1H2O has m 196-197.5o (dec with sintering at 160-165o) after crystallisation from Et2O. Serotonin is a natural neurotransmitter [Chuang Life Sci 41 1051 1987]. [Beilstein 22/12 V 16.]

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