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4-amino-2-fluoro-N-methylbenzamide

Basic information Safety Supplier Related

4-amino-2-fluoro-N-methylbenzamide Basic information

Product Name:
4-amino-2-fluoro-N-methylbenzamide
Synonyms:
  • 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE
  • N-Methyl-2-fluoro-4-aminobenzamide
  • BenzaMide, 4-aMino-2-fluoro-N-Methyl-
  • 2. 4-aMino-2-fluoro-N-MethylbenzaMide
  • N-Methyl-4-amino-2-fluoro-benzamide
  • 4-amino-2-fluoro-N-menthylbenzamide
  • Enzalutamide Impurity 20
  • Enzalutamide ITS-3
CAS:
915087-25-1
MF:
C8H9FN2O
MW:
168.17
Product Categories:
  • 915087-25-1
Mol File:
915087-25-1.mol
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4-amino-2-fluoro-N-methylbenzamide Chemical Properties

Melting point:
160 - 163°C
Boiling point:
320℃
Density 
1.234
Flash point:
147℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.12±0.46(Predicted)
color 
White to Off-White
Stability:
Moisture Sensitive
InChI
InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)
InChIKey
XOKAXPQJUODMSH-UHFFFAOYSA-N
SMILES
C(NC)(=O)C1=CC=C(N)C=C1F
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Safety Information

HS Code 
2924297099
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4-amino-2-fluoro-N-methylbenzamide Usage And Synthesis

Uses

4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.

Description

4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.

Preparation

2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.

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