CCG 2046 Chemical Properties

Boiling point:

467.4±45.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

<19.82mg/ml in DMSO

CCG 2046 Usage And Synthesis

Uses

CCG-2046 is a RGS4 inhibitor with an IC50 of 4.3 μM against RGS4-Gαo interaction signal[1].

Biological Activity

Inhibitor of regulator of G-protein signaling 4 (RGS4). Reduces the RGS4-G α o protein-protein interaction signal.

IC 50

RGS4: 4.3 μM (IC₅₀)

References

[1] Roman DL, et al. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Mol Pharmacol. 2007 Jan;71(1):169-75. DOI:10.1124/mol.106.028670

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