5,6,7,8-TETRAHYDRO-1-NAPHTHOL Chemical Properties

Melting point:

69-71 °C(lit.)

Boiling point:

264-265 °C705 mm Hg(lit.)

Density 

1.0556

refractive index 

1.5000 (estimate)

Flash point:

264-265°C/705mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

pK1:10.28 (25°C)

color 

Off-White to Pale Orange

BRN 

1865081

InChIKey

SCWNNOCLLOHZIG-UHFFFAOYSA-N

CAS DataBase Reference

529-35-1(CAS DataBase Reference)

EPA Substance Registry System

1-Naphthalenol, 5,6,7,8-tetrahydro- (529-35-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

29071990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5,6,7,8-TETRAHYDRO-1-NAPHTHOL Usage And Synthesis

Uses

5,6,7,8-Tetrahydro-1-naphthol is a useful chemical intermediate, widely applied in organic synthesis and also used as a fuel additive.

Industrial Production

5,6,7,8-Tetrahydro-1-naphthol can be produced through partial reduction of aromatic ring of 1-naphthol by various homogeneous or heterogeneous catalytic hydrogenation methods.

Chemical Properties

white to slightly pink crystalline mass or

Uses

5,6,7,8-Tetrahydro-1-naphthalenol was used as a reagent in the synthesis of phosphonamidate and phosphonodiamidate prodrugs of adefovir and tenofovir which are used in the treatment of HIV infections. Also used in the synthesis of tetrahydronaphthalene-1-ol derivatives which were found to be promising potent antitumor agents.

Definition

ChEBI: 5,6,7,8-tetrahydro-1-naphthol is 1-naphthol hydrogenated at C-5, -6, -7 and -8.

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