CYNARIN Chemical Properties

Boiling point:

819.9±65.0 °C(Predicted)

Density 

1?+-.0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

soluble5mg/mL, clear, colorless to light yellow

pka

2.50±0.50(Predicted)

color 

white to off-white

Stability:

Hygroscopic

Safety Information

WGK Germany 

3

CYNARIN Usage And Synthesis

Description

1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger. 1,5-DCQA inhibits HIV-1 integrase 3'' end processing, end joining, and disintegration with IC₅₀ values of 0.35, 0.56, and 0.84 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED₅₀value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe (fMLP; ) in a dose-dependent manner. It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 μM.

Uses

1,5-Dicaffeoylquinic Acid acts as an anti-hyperlipidemic agent. In addition, acts as a neuroprotective agent against amyloid-β toxicity in the treatement of Alzheimer’s.

CYNARIN(19870-46-3)Related Product Information

• Cynarin
• Isochlorogenic Acid B
• Cryptochlorogenic acid
• CAFTARIC ACID
• 1-Caffeoylquinic acid
• Isochlorogenic acid A
• Chlorogenic acid
• 1,3,5-Tricaffeoylquinic acid
• Isochlorogenic acid C
• 2,3,4,5-Tetracaffeoyl-D-Glucaric acid
• Neochlorogenic acid