2-Amino-6-chloro-3-nitropyridine Chemical Properties

Melting point:

195-196

Boiling point:

339.9±37.0 °C(Predicted)

Density 

1.596±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform, DMSO

form 

Crystalline

pka

-1.69±0.50(Predicted)

color 

Yellow

Water Solubility 

Slightly soluble in water. Soluble in dimethyl sulfoxide and chloroform.

InChI

InChI=1S/C5H4ClN3O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H,(H2,7,8)

InChIKey

WERABQRUGJIMKQ-UHFFFAOYSA-N

SMILES

C1(N)=NC(Cl)=CC=C1[N+]([O-])=O

CAS DataBase Reference

27048-04-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-26-36/37/39

RIDADR 

2811

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29333999

MSDS

• Language:English Provider:2-Amino-6-chloro-3-nitropyridine
• Language:English Provider:SigmaAldrich

2-Amino-6-chloro-3-nitropyridine Usage And Synthesis

Description

2-Amino-6-chloro-3-nitropyridine is a cytotoxic drug that has been shown to have anti-viral potency, as well as antiviral activity in an activity test. It is synthesized by reacting hydrogen tartrate with oxadiazole, and then hydrolyzing the resulting product with chloride. 2-Amino-6-chloro-3-nitropyridine has also been shown to inhibit human immunodeficiency virus type 1 (HIV) replication in vitro and to be effective against other viruses such as type 2 influenza. This drug can bind to the viral envelope and inhibit fusion of the viral membrane with host cells by preventing the release of viral contents into the cytoplasm. The binding affinity of 2-amino 6-chloro 3 nitropyridine for chloride may be due to hydrogen bonding interactions.

Chemical Properties

YELLOW POWDER

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

The 2-Amino-6-chloro-3-nitropyridine may be obtained by the ammonolysis of 2,6-dichloro-3-nitropyridine by a known process. The ammonolysis is carried out by using solution of aqueous ammonia in methanol at 35°–40° C. After the reaction is over, the product is obtained by filtration.

2-Amino-6-chloro-3-nitropyridine(27048-04-0)Related Product Information

• 4-Chloro-3-nitropyridine
• Aniline
• Bis(2-ethylhexyl)amine
• Clopidol
• 1-Chloro-3-nitrobenzene
• 3-Nitropyridine
• 2-Chloro-3-nitropyridine
• Glycine
• 4-Dimethylaminopyridine
• Epichlorohydrin
• 2-Amino-5-nitropyridine
• 2-Amino-3-nitropyridine
• ALTRENOGEST
• 2-Aminopyridine
• 3-Aminopyridine
• Betaine
• Pentachloropyridine
• 2-Amino-6-chloropyridine