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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride

Basic information Safety Supplier Related

1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Basic information

Product Name:
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
Synonyms:
  • 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
  • 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride
  • Org 12962 hydrochloride
  • Org12962HCl
  • Org 12692
  • Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-, hydrochloride (1:1)
CAS:
210821-63-9
MF:
C10H11ClF3N3.ClH
MW:
302.126
Mol File:
210821-63-9.mol
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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Chemical Properties

storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble to 50 mM in water and to 100 mM in DMSO
form 
Pale yellow solid.
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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Usage And Synthesis

Uses

Org 12962 Hydrochloride is a receptor agonists that helps in the anxiety models in rats.

Biological Activity

Selective 5-HT 2C receptor agonist (pEC 50 values are 7.01, 6.38 and 6.28 for 5-HT 2C , 5-HT 2A and 5-HT 2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.

in vivo

Org 12962 (intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3].

Animal Model:Male Wistar rats[3]
Dosage:0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration:Intraperitoneal?injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result:Had a dose-related antipanic-like effect in SD-rat.

IC 50

5-HT2C Receptor: 7.01 (pEC50); 5-HT2A Receptor: 6.38 (pEC50); 5-HT2B Receptor: 6.28 (pEC50)

1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochlorideSupplier

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1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride(210821-63-9)Related Product Information