Pamoic acid disodium salt Chemical Properties

Melting point:

300 °C

Density 

1.55[at 20℃]

vapor pressure 

0.001Pa at 25℃

storage temp. 

Desiccate at RT

solubility 

insoluble in EtOH; ≥18 mg/mL in H2O; ≥28.6 mg/mL in DMSO

form 

solid

color 

Pale yellow

Water Solubility 

43g/L at 20℃

LogP

-3.2 at 20℃

CAS DataBase Reference

6640-22-8(CAS DataBase Reference)

EPA Substance Registry System

2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, disodium salt (6640-22-8)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-37/38-41-48

Safety Statements 

24/25-45-36/37/39-26-22

WGK Germany 

3

HS Code 

2918.29.7500

MSDS

• Language:English Provider:4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt
• Language:English Provider:ACROS

Pamoic acid disodium salt Usage And Synthesis

Chemical Properties

pale yellow to yellow powder

Uses

Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer.

Flammability and Explosibility

Not classified

Biological Activity

Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

Pamoic acid disodium salt(6640-22-8)Related Product Information

• Sodium Phosphate, Dibasic
• Sodium phosphate dibasic dodecahydrate
• Pamoic acid
• 1,1'-METHYLENEDI-2-NAPHTHOL
• 2,2'-METHYLENEDIPHENOL
• 2-Naphthoic acid
• Sodium diacetate
• 2-Naphthalenemethanol
• 3-Hydroxy-2-naphthoic acid
• Sodium salicylate
• 3-Methylsalicylic acid
• 1,3-DIMETHYLNAPHTHALENE
• Pamoic acid disodium salt
• 2-HYDROXY-3-NAPHTHOIC ACID SODIUM SALT
• EMBONIC ACID
• 2-NAPHTHALENECARBOXYLIC ACID SODIUM SALT
• 3,3'-DICARBOXYDIPHENYLMETHANE
• 3-METHYLSALICYLIC ACID SODIUM SALT