2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Basic information
- Product Name:
- 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
- Synonyms:
-
- Comins Reagent, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine, 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
- N-(5-CHLORO-2-PYRIDYL)BIS(TRILFUOROMETHANESULFONIMIDE)
- N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
- 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine ,98%
- Comins Triflating Reagent
- N-(5-Chloro-2-pyridyl)triflimide N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide Comins Triflating Reagent
- N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoroMethane)sulfonylMethanesulfonaMide
- 2-{Bis[(trifluoromethyl)sulphonyl]amino}-5-chloropyridine
- CAS:
- 145100-51-2
- MF:
- C7H3ClF6N2O4S2
- MW:
- 392.68
- EINECS:
- 629-110-2
- Product Categories:
-
- Chloropyridines
- Halopyridines
- Mol File:
- 145100-51-2.mol
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Chemical Properties
- Melting point:
- 45-47 °C(lit.)
- Boiling point:
- 77-90°C/0.2mmHg
- Density
- 1.892±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Benzene (Slightly)
- form
- Solid
- pka
- -7.71±0.10(Predicted)
- color
- yellow
- Water Solubility
- Reacts with water.
- Sensitive
- Moisture Sensitive
- BRN
- 5833971
- Stability:
- Moisture Sensitive, Unstable in DMSO Solution
- InChIKey
- TUFGVZMNGTYAQD-UHFFFAOYSA-N
- CAS DataBase Reference
- 145100-51-2(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Usage And Synthesis
Chemical Properties
White to pale yellow crystalline solid
Uses
2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.
Uses
Reactant for:
Suzuki-Miyaura cross coupling
Synthesis of nicotinic acetylcholine receptor-selective ligands
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions
Synthesis of high affinity niacin receptor GPR109A agonists
Preparation of heteroaromatics
2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINESupplier
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