PHA-680632 Chemical Properties

Melting point:

240-242 °C

Boiling point:

709.0±60.0 °C(Predicted)

Density 

1.294

storage temp. 

Store at -20°C

solubility 

≥50.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

form 

Powder

pka

12.26±0.70(Predicted)

PHA-680632 Usage And Synthesis

Uses

PHA-680632 is a potent and selective inhibitor of Aurora kinase.

Biological Activity

pha-680632 is a novel and potent inhibitor of aurora kinases, a small family of serine/threonine kinases regulating mitosis in chromosome segregation and cell division, that inhibits the activity of all three aurora kinases with 50% inhibition concentration ic50 values of 27 nm, 135 nm and 120 nm for aurora a, b and c kinases respectively. pha-680632 also cross-reacts with other kinases, including fgfr1, flt3, lck, plk1, stlk2, vegfr2 and vegfr3, to a lesser extent and exhibits much higher ic50 values (390 to 5500 nm) compared to aurora kinases. moreover, pha-680632 potently inhibits proliferation in a wide range of cancer cell types, including hct116, a2780, hl60 and hela cells, with ic50 values ranging from 0.06 to 7.15 μm.soncini c, carpinelli p, gianellini l, fancelli d, vianello p, rusconi l, storici p, zugnoni p, pesenti e, croci v, ceruti r, giorgini ml, cappella p, ballinari d, sola f, varasi m, bravo r, moll j. pha-680632, a novel aurora kinase inhibitor with potent antitumoral activity. clin cancer res. 2006 jul 1;12(13):4080-9.

target

Aurora A

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