2-Bromo-4-methylpyridine Chemical Properties

Boiling point:

87 °C/10 mmHg (lit.)

Density 

1.545 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.561(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol (Slightly)

pka

1.46±0.10(Predicted)

form 

Liquid

color 

Clear yellow

Specific Gravity

1.545

BRN 

107331

InChI

InChI=1S/C6H6BrN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3

InChIKey

LSZMVESSGLHDJE-UHFFFAOYSA-N

SMILES

C1(Br)=NC=CC(C)=C1

CAS DataBase Reference

4926-28-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:2-Bromo-4-methylpyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Bromo-4-methylpyridine Usage And Synthesis

Chemical Properties

Colorless to orange oily liqui

Uses

An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity

Uses

2-Bromo-4-methylpyridine may be used:

• in the total synthesis of ocular age pigment A2-E (2 equiv of retinal (vitamin A) and 1 equiv of ethanolamine)
• in the preparation of methoxy-2-(2-pyridyl)indoles
• in the preparation of 2-(2′,4′-difluorophenyl)-4-methylpyridine, via a Suzuki coupling reaction with 2,4-difluorophenylboronic acid

Application

2-Bromo-4-methylpyridine can be used as an intermediate in organic synthesis and medicinal chemistry, mostly in the structural modification and synthesis of drug molecules. In basic chemistry research, the substance can be used for the synthesis of a series of organic nitrogen ligands containing pyridine units, and has good applications in the basic research of methodology of transition metal catalysis.

2-Bromo-4-methylpyridine(4926-28-7)Related Product Information

• 2-Bromo-5-nitro-4-picoline
• Azamethiphos
• 1-Hexadecylpyridinium bromide
• 2,4,6-Collidine
• 2-Bromo-4-nitropyridine
• 2-Bromopyridine-4-carboxylic acid
• 4-Methylpyridine
• 2,6-Lutidine
• 2-Chloro-5-chloromethylpyridine
• 5-AMINO-2-BROMO-3-METHYLPYRIDINE
• 2-BROMO-3-METHYLPYRIDINE
• 2-Bromo-3-methylbenzaldehyde
• 2-Bromo-4-nitroimidazole
• 2-Bromo-4-fluoropyridine
• 2-Bromo-5,6-diphenylpyrazine
• 2-Bromo-3-trifluoromethylpyridine
• 2-Bromo-4-chloropyridine
• 2-Bromo-3-fluoropyridine