4-AMino-5-Methylpyridin-2-ol Chemical Properties

Boiling point:

291.0±33.0℃ (760 Torr)

Density 

1.137±0.06 g/cm3 (20 ºC 760 Torr)

vapor pressure 

0-0Pa at 20-50℃

Flash point:

129.8±25.4℃

storage temp. 

2-8°C(protect from light)

pka

11.90±0.10(Predicted)

InChI

InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)

InChIKey

SSQZBQXJYGNUSC-UHFFFAOYSA-N

SMILES

C1(=O)NC=C(C)C(N)=C1

LogP

-0.51 at 20℃ and pH6.3

CAS DataBase Reference

95306-64-2

4-AMino-5-Methylpyridin-2-ol Usage And Synthesis

Description

4-AMino-5-Methylpyridin-2-ol belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules. For example, the compound can prepare selective mineralocorticoid receptor (MR) antagonist finerenone, which is used to lower the risk of severe kidney and heart problems.

Uses

4-Amino-5-methylpyridin-2(1H)-one has been used as a reactant for the synthesis of BAY 94-8862, a nonsteroidal antagonist of the mineralocorticoid receptor to be used for the treatment of cardiorenal diseases.

Synthesis

2-Chloro-4-amino-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.

4-AMino-5-Methylpyridin-2-ol(95306-64-2)Related Product Information

• 4-AMino-5-benzyl-pyriMidine-2-thiol