Δ2-Cefepime
Δ2-Cefepime Basic information
- Product Name:
- Δ2-Cefepime
- Synonyms:
-
- Δ2-Cefepime
- Δ2-CefepiMe Etherate
- (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate,ethoxyethane
- 1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-en-3-yl]Methyl]-1-MethylpyrrolidiniuM Inner Salt Etherate
- Δ2-CefepiMe Etherate Dihydrochloride Salt
- Cefepime Δ - 3 Isomer
- Δ2-Cefepime
- Cefepime Δ - 3 Isomer
- CAS:
- 88040-25-9
- MF:
- C23H34N6O6S2
- MW:
- 554.68266
- Product Categories:
-
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 88040-25-9.mol
Δ2-Cefepime Chemical Properties
- Melting point:
- >151°C (dec.)
- storage temp.
- Amber Vial, -20°C Freezer, Under Inert Atmosphere
- solubility
- Water (Slightly)
- form
- Solid
- color
- White to Off-White
- InChIKey
- DBCVQAGQPYVVDA-XVKMNWMGSA-N
Δ2-Cefepime Usage And Synthesis
Uses
Δ2-Cefepime is the Δ2-isomer of Cefepime (C242750), a new series of cephalosporins.
Uses
The Δ2-isomer of Cefepime (C242750), a new series of cephalosporins.
Preparation
First, cefepime and N-trimethylsilylacetamide were added to dichloromethane for 0.5 h. Subsequently, triethylamine dissolved in dichloromethane was added to the reaction system between 2-5 °C. Adjust the temperature to 2-5 °C and react for 24 h. After adding water, the aqueous layer was separated, and the aqueous phase was washed with methylene chloride. Wait for the solution to cool to 2-5 °C and adjust the pH=3 with sulfuric acid. Stir the resulting slurry for 2h. Filter to collect the solids and wash with water, adjust the pH=7.5-8.0 with sodium bicarbonate aqueous solution, add carbon, and stir for 30 min. Filter the mixture to collect the filtrate and adjust pH=3 with sulfuric acid. Finally, the solids are filtered and collected, and product Δ2-Cefepime is obtained by washing and drying.
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