ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > PI3K / Akt / mTOR > PI3K inhibitor > XL147
XL147
XL147 Basic information
- Product Name:
- XL147
- Synonyms:
-
- SAR245408
- XL147;XL-147;SAR245408
- N-[3-(Benzo[c][1,2,5]thiadiazol-5-ylaMino)quinoxalin-2-yl]-4-MethylbenzenesulfonaMide
- N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide,
- XL147
- XL-147(SAR245408)
- PI3K inhibitorX
- N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide XL 147
- CAS:
- 956958-53-5
- MF:
- C21H16N6O2S2
- MW:
- 448.52
- Product Categories:
-
- Akt
- mTOR
- Amines
- Aromatics
- Inhibitors
- PI3K
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 956958-53-5.mol
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XL147 Chemical Properties
- Boiling point:
- 638.9±65.0 °C(Predicted)
- Density
- 1.538
- storage temp.
- Store at -20°C
- solubility
- ≥22.45 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 6.71±0.30(Predicted)
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XL147 Usage And Synthesis
Description
XL147 analog is an analog of XL147 .
Uses
XL147 analogue is one of Pyrimidine derivatives as JAK-2 inhibitors in combination with other agents and their use in the treatment of diseases.
Definition
ChEBI: XL147 is a sulfonamide that is the N-4-toluenesulfonyl (N-tosyl) derivative of N-(2,1,3-benzothiadiazol-5-yl)quinoxaline-2,3-diamine. A selective PI3K inhibitor used in cancer treatment. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a sulfonamide, a quinoxaline derivative, a benzothiadiazole and an aromatic amine.
target
PI3Kα
XL147Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Chembest Research Laboratories Limited
- Tel
- 021-20908456
- sales@BioChemBest.com
BeiJing Hwrk Chemicals Limted
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
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XL147(956958-53-5)Related Product Information
- pilaralisib
- Cabozantinib
- BMS 833923
- XL019
- Obeticholic Acid
- MK-4101
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- GDC-0068
- Alpelisib (BYL719)
- Dasatinib
- CAL-101
- Perifosine (KRX-0401)
- XL-388
- XL-652
- XL-765,SAR245409
- 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester
- XL-019