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XL147

Basic information Safety Supplier Related

XL147 Basic information

Product Name:
XL147
Synonyms:
  • SAR245408
  • XL147;XL-147;SAR245408
  • N-[3-(Benzo[c][1,2,5]thiadiazol-5-ylaMino)quinoxalin-2-yl]-4-MethylbenzenesulfonaMide
  • N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide,
  • XL147
  • XL-147(SAR245408)
  • PI3K inhibitorX
  • N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide XL 147
CAS:
956958-53-5
MF:
C21H16N6O2S2
MW:
448.52
Product Categories:
  • Akt
  • mTOR
  • Amines
  • Aromatics
  • Inhibitors
  • PI3K
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
Mol File:
956958-53-5.mol
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XL147 Chemical Properties

Boiling point:
638.9±65.0 °C(Predicted)
Density 
1.538
storage temp. 
Store at -20°C
solubility 
≥22.45 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form 
solid
pka
6.71±0.30(Predicted)
color 
Light brown to brown
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XL147 Usage And Synthesis

Description

XL147 analog is an analog of XL147 .

Uses

XL147 analogue is one of Pyrimidine derivatives as JAK-2 inhibitors in combination with other agents and their use in the treatment of diseases.

Definition

ChEBI: XL147 is a sulfonamide that is the N-4-toluenesulfonyl (N-tosyl) derivative of N-(2,1,3-benzothiadiazol-5-yl)quinoxaline-2,3-diamine. A selective PI3K inhibitor used in cancer treatment. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a sulfonamide, a quinoxaline derivative, a benzothiadiazole and an aromatic amine.

target

PI3Kα

XL147Supplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Chembest Research Laboratories Limited
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+86-21-20908456
Email
sales@BioChemBest.com
BeiJing Hwrk Chemicals Limted
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0757-86329057 18934348241
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sales4.gd@hwrkchemical.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
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XL147(956958-53-5)Related Product Information