N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties

Melting point:

167-173℃

Boiling point:

524.4±35.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)

pka

2.82±0.30(Predicted)

Stability:

Hygroscopic

CAS DataBase Reference

444731-75-3

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Usage And Synthesis

Chemical Properties

Light Beige to Beige Solid

Uses

N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Synthesis

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine(444731-75-3)Related Product Information

• 5-BROMO-3-METHYLINDOLE
• 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
• 1,3-DiMethyl-6-aMino-1H-indazole
• 4(1H)-Pyrimidinone, 2-chloro- (9CI)
• 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide
• N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
• Pazopanib-d6
• 2,3-dimethyl-2H-indazol-6-amine hydrochloride
• Pazopanib Impurity 9
• Pazopanib
• Pazopanib Related Compound 2
• 1,3-Dimethyl-6-nitro-1H-indazole
• Pazopanib Related Compound 3
• 3-Methyl-6-nitro-2H-indazole
• 4-Acetoxy-3-acetoxymethylacetophenone
• (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
• (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid
• Pazopanib Impurity 10