alpha, oMega-DisucciniMidyl hexaethylene glycol Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Viscous Liquid

color 

Colorless to light yellow

alpha, oMega-DisucciniMidyl hexaethylene glycol Usage And Synthesis

Description

Bis-PEG7-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Biological Activity

Bis-PEG7-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

target

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Mahendra Persaud Deonarai, et al. Biological materials and uses thereof. WO2016046574A1

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