Basic information Safety Supplier Related

alpha, oMega-DisucciniMidyl hexaethylene glycol

Basic information Safety Supplier Related

alpha, oMega-DisucciniMidyl hexaethylene glycol Basic information

Product Name:
alpha, oMega-DisucciniMidyl hexaethylene glycol
Synonyms:
  • alpha, oMega-DisucciniMidyl hexaethylene glycol
  • NHS-PEG6-NHS
  • Bis-PEG7-NHS ester
  • α,ω-disuccinimidyl hexaethylene glycol
  • 4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid, 1,25-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • Bis-dPEG7-NHS ester
  • Di-NHS Ester-PEG7
  • (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxo-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CAS:
1334170-02-3
MF:
C26H40N2O15
MW:
620.6
Product Categories:
  • Homobifunctional PEG
Mol File:
1334170-02-3.mol
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alpha, oMega-DisucciniMidyl hexaethylene glycol Chemical Properties

solubility 
Soluble in DMSO, DCM, DMF
form 
Viscous Liquid
color 
Colorless to light yellow
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alpha, oMega-DisucciniMidyl hexaethylene glycol Usage And Synthesis

Description

Bis-PEG7-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Biological Activity

Bis-PEG7-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

target

Cleavable

PEGs

Alkyl/ether

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