5-BroMoquinoline-8-carboxylic acid Chemical Properties

Boiling point:

425.9±30.0 °C(Predicted)

Density 

1.732±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-2.39±0.10(Predicted)

Appearance

Light brown to brown Solid

5-BroMoquinoline-8-carboxylic acid Usage And Synthesis

Synthesis

Step 2: 5-bromo-8-methylquinoline (from Step 1) was dissolved in H2SO4-H2O (3:2) to prepare a 0.1 M solution. CrO3 (10 equiv.) was added to this solution and the reaction was carried out at 90 °C for 2 hours. After completion of the reaction, the mixture was poured into ice water and the precipitate was collected by filtration to afford 5-bromoquinoline-8-carboxylic acid in 62% yield as an orange solid. Mass spectrum (ES+) m/z 252,254 (M+H)+.

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 8, p. 2836 - 2848
[2] Patent: WO2007/28789, 2007, A1. Location in patent: Page/Page column 34
[3] Patent: WO2013/96194, 2013, A1
[4] Patent: WO2015/84842, 2015, A1. Location in patent: Paragraph 0089
[5] Patent: WO2009/141386, 2009, A1. Location in patent: Page/Page column 162; 163

5-BroMoquinoline-8-carboxylic acid(928839-62-7)Related Product Information

• Methyl 5-broMoquinoline-8-carboxylate
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• 5-broMoquinoline-8-carbonitrile
• Methyl 5-broMoquinoline-2-carboxylate
• 5-BROMOQUINOLINE-8-CARBALDEHYDE
• 5-BroMoquinoline-2-carboxylic acid
• 5-BROMOQUINOLIN-2-AMINE
• ethyl 5-bromoquinoline-3-carboxylate
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• 6-BROMOQUINOLINE-4-CARBOXYLIC ACID
• 5-BROMO-1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID
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• 5-NITROBENZOFURAN-2-CARBOXYLIC ACID
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• 8-broMoquinoline-2-carbaldehyde