Methyl 4-(4-oxobutyl)benzoate Chemical Properties

Melting point:

76.5-78 °C(Solv: ethyl ether (60-29-7))

Boiling point:

131 °C(Press: <1 Torr)

Density 

1.082±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Oil

color 

Clear Colourless

Stability:

Hygroscopic

Methyl 4-(4-oxobutyl)benzoate Usage And Synthesis

Uses

4-(4-Oxobutyl)benzoic Acid Methyl Ester is used as a reagent in the preparation of Pemetrexed (P219500) and furoxanoxyalkyl esters of Pemetrexed as antifolates and nitric oxide donors for use as anticancer agents.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 1, 1986 DOI: 10.1002/jhet.5570230101

Methyl 4-(4-oxobutyl)benzoate(106200-41-3)Related Product Information

• Pemetrexed Disodium
• 2,4-Diamino-6-hydroxypyrimidine
• Pemetrexed Impurity 19
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester
• Methyl 4-(4-hydroxybut-1-ynyl)benzoate
• Pemetrexed Impurity 11
• Pemetrexed
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid
• 5-BroMopyriMidine-2,4,6(1H,3H,5H)-trione
• PeMetrexed EP IMpurity A
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-dimethyl ester
• Benzoic acid, 4-(1-methyl-3-oxopropyl)-, methyl ester (9CI)
• Methyl 4-bromobenzoate
• PeMetrexed EP IMpurity C
• PeMetrexed IMpurity D
• 3-Buten-1-ol
• N-[4-[3-(2,6-DiaMino-1,4-dihydro-4-oxo-5-pyriMidinyl)-3-oxopropyl]benzoyl]-L-glutaMic Acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester