ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Cell Cycle > Aurora Kinase Inhibitors > CCT129202
CCT129202
CCT129202 Basic information
- Product Name:
- CCT129202
- Synonyms:
-
- CCT129202
- 2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide
- 2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th
- CCT129202 (CCT-129202
- CS-407
- CCT129202 USP/EP/BP
- 1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-
- CAS:
- 942947-93-5
- MF:
- C23H25ClN8OS
- MW:
- 497.02
- Product Categories:
-
- Inhibitor
- Inhibitors
- Mol File:
- 942947-93-5.mol
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CCT129202 Chemical Properties
- Density
- 1.427
- storage temp.
- Store at -20°C
- solubility
- DMSO : 1 mg/mL (2.01 mM; Need ultrasonic)
- form
- Powder
- pka
- 9.26±0.50(Predicted)
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CCT129202 Usage And Synthesis
Biological Activity
CCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc.
in vivo
CCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%.
target
Aurora A
CCT129202Supplier
Chembest Research Laboratories Limited
- Tel
- 021-20908456
- sales@BioChemBest.com
Jinan Trio PharmaTech Co., Ltd.
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
NCE Biomedical Co.,Ltd.
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel
- 18521735133 18521732826;
- market@aladdin-e.com