Rhynchophylline
Rhynchophylline Basic information
- Product Name:
- Rhynchophylline
- Synonyms:
-
- RHYNCHOLPHYLLINE
- RHYNCHOPHYLLINE
- MITRINERMINE
- 16e,20-alpha)-(7-bet
- mitrinermin
- Rhynchophylline 76-66-4
- Hook vine extract
- rhynchophyllin
- CAS:
- 76-66-4
- MF:
- C22H28N2O4
- MW:
- 384.47
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Alkaloids
- API
- Mol File:
- 76-66-4.mol
Rhynchophylline Chemical Properties
- Melting point:
- 216°; mp 197-199° (Ban et al., loc. cit.)
- alpha
- D13 -14.7° (c = 2.5 in chloroform)
- Boiling point:
- 560.8±50.0 °C(Predicted)
- Density
- 1.23
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.4(at 25℃)
- color
- White to Off-White
- λmax
- 247nm(lit.)
- Merck
- 14,8197
- Stability:
- Hygroscopic
- InChIKey
- DAXYUDFNWXHGBE-QCJVZUPCSA-N
- LogP
- 3.311 (est)
- CAS DataBase Reference
- 76-66-4
Rhynchophylline Usage And Synthesis
Chemical Properties
Soluble in chloroform, acetone, ethanol, benzene, slightly soluble in ether and ethyl acetate, almost insoluble in petroleum ether. Derived from the hooked branches of Uncaria rhynchopylla (Miq.) Jacks.
Uses
Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.
Definition
ChEBI: A natural product found in Uncaria macrophylla.
in vivo
Rhynchophylline (10 and 30 mg/kg, i.p., once daily for 4 days) protects rats from pMCAO surgery induced ischemic brain damage[2].
Rhynchophylline (100 μM, 2 μL, injected bilaterally in the hippocamp) shows neuroprotective effects against Aβ1-42-induced neurotoxicity in rats[5].
Rhynchophylline (50 mg/kg, p.o., daily, 3-4 weeks) inhibits EphA4 activation in the hippocampus of APP/PS1 mice[6].
| Animal Model: | Aβ1-42(1.6 μM, 2 μL) treated rats[5] |
| Dosage: | 100 μM, 2 μL |
| Administration: | injected bilaterally in the hippocamp |
| Result: | Rescued the soluble Aβ1-42-induced spatial learning and memory deficits. Inhibited Aβ1-42-induced excessive activation of extrasynaptic NMDARs. |
References
See Rhyncophylline
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