Deoxycytidine triphosphate trisodium salt Chemical Properties

storage temp. 

-20°C

solubility 

Water: 10 mg/ml

form 

A crystalline solid

color 

Colorless to light yellow

Water Solubility 

Water: 10 mg/ml

InChI

InChI=1/C9H16N3O13P3.3Na/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17);;;/q;3*+1/p-3/t5-,6+,8+;;;/s3

InChIKey

WBIPTAOOMJEGQO-JXXKLNQHNA-K

SMILES

N1(C=CC(N)=NC1=O)[C@H]1C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)O)O1.[Na+].[Na+].[Na+] |&1:8,10,12,r|

CAS DataBase Reference

109909-44-6(CAS DataBase Reference)

Deoxycytidine triphosphate trisodium salt Usage And Synthesis

Description

Deoxycytidine triphosphate trisodium salt (dCTP trisodium salt or 2′-Deoxycytidine-5′-triphosphate trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

Uses

Deoxycytidine triphosphate trisodium salt (2′-Deoxycytidine-5′-triphosphate trisodium salt) is an activator that has been shown to exhibit anticancer and antiviral activities. It is a novel nucleoside phosphoramidite that is used in the synthesis of DNA, RNA, and other nucleic acids. 2′-Deoxycytidine-5′-triphosphate trisodium salt has been modified by substituting the oxygen atom for a sulfur atom at the 5' position of the sugar moiety. This change makes it resistant to degradation by ribonucleases. 2′-Deoxycytidine-5′-triphosphate trisodium salt has also been shown to act as an inhibitor of human telomerase activity.

in vitro

Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-β-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2′-Deoxycytidine-5′-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C.
Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate.

Deoxycytidine triphosphate trisodium salt(109909-44-6)Related Product Information

• Sodium phosphate tribasic dodecahydrate
• 2'-Deoxycytidine
• Trisodium phosphate
• Cytosine
• 5-Methyl-2'-deoxycytidine
• 2'-Deoxycytidine-5'-triphosphoric acid disodium salt
• Cytidine 5′-(tetrahydrogen triphosphate), xsodium salt, hydrate
• Cytidine-5'-triphosphate disodium salt dihydrate
• Deoxycytidine triphosphate trisodium salt
• CTP 3H TETRASODIUM SALT
• DCTP, [5-3H] TETRASODIUM SALT
• 5-PROPARGYLAMINO-2'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, SODIUM SALT
• 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, TRISODIUM SALT, DIHYDRATE
• 2'-DEOXYCYTIDINE--5'-TRIPHOSPHATE ,TRISODIUM SALT ( DCTP,3NA)
• DCTP, TETRASODIUM SALT, [5,5'-3H]-
• 2'-DEOXY-5-METHYLCYTIDINE 5'-TRIPHOSPHATE, SODIUM SALT
• 2'-DEOXY-N4-METHYLCYTIDINE 5'-TRIPHOSPHATE, SODIUM SALT
• 2'-DEOXYCYTIDINE-13C9,15N3 5'-TRISPHOSPHATE SODIUM SALT