6-BroMo-5-chloro-pyridine-2-carboxylic acid Chemical Properties

Boiling point:

374.5±42.0 °C(Predicted)

Density 

1.917±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

3.02±0.10(Predicted)

form 

solid

color 

Off white

Safety Information

HS Code 

2933399990

6-BroMo-5-chloro-pyridine-2-carboxylic acid Usage And Synthesis

Uses

6-Bromo-5-chloro-pyridine-2-carboxylic acid is a carboxylic acid derivative used in organic synthesis and pharmaceutical experiments.

Synthesis

5-Chloro-1-yloxy-pyridine-2-carboxylic acid (3.5 g, 20 mmol) was slowly added to phosphorus trioxide (CAS 7789-59-5, 30 g) at 80 °C and the reaction was kept stirring for 2 hours. Upon completion of the reaction, the reaction mixture was quenched by careful pouring into ice water (100 mL) and subsequently extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by column chromatography (silica gel 100 g, eluent 50% petroleum ether solution of ethyl acetate) to give 2-bromo-3-chloro-6-carboxypyridine (1.12 g, 23% yield) as a gray solid. Mass spectrometry (EI) analysis showed: m/e 236.0 [M+H]+.

References

[1] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 55
[2] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 119; 120

6-BroMo-5-chloro-pyridine-2-carboxylic acid(1214328-42-3)Related Product Information

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• 6-Bromo-4-methyl-indan-1-one
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• 6-BroMo-5-fluoro-2,3-dihydro-1H-inden-1-one
• 6-Bromo-5-methoxypicolinic acid
• 6-BroMo-5-chloro-nicotinic acid Methyl ester
• 6-BroMo-5-Methoxypicolinonitrile
• Methyl 6-broMo-5-Methylpicolinate
• 2-Pyridinecarboxylic acid, 6-broMo-5-Methoxy-, Methyl ester
• 6-BROMO-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIDINE
• 6-BROMO-5-IODOPYRIDIN-3-AMINE
• 2-Bromo-6-cyano-3-methylpyridine
• 6-BroMo-5-Methoxypicolinaldehyde
• methyl 6-bromo-5-hydroxy-2-pyridinecarboxylate
• 6-BroMo-5-chloropicolinaldehyde
• 6-broMo-5-(trifluoroMethyl)pyridin-3-aMine