Y 11 Chemical Properties

storage temp. 

-20°C

solubility 

H2O: soluble25mg/mL, clear

form 

powder

color 

white to beige

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

36/37/39

WGK Germany 

3

Y 11 Usage And Synthesis

Uses

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397. At 100 μM, it was shown to decrease cell viability of T47D breast cancer and C8161 melanoma cell lines.[Cayman Chemical]

Uses

Y 11 is a potent inhibitor of focal adhesion kinase (FAK); Y 11 prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Y 11 decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.

Y 11(1086639-59-9)Related Product Information

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