FX-11 Chemical Properties

Melting point:

183-184 °C

Boiling point:

570.1±50.0 °C(Predicted)

Density 

1.260±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

3.70±0.40(Predicted)

color 

Light Grey to Light Brown

InChI

InChI=1S/C22H22O4/c1-3-7-16-17-10-13(2)15(11-14-8-5-4-6-9-14)12-18(17)19(22(25)26)21(24)20(16)23/h4-6,8-10,12,23-24H,3,7,11H2,1-2H3,(H,25,26)

InChIKey

LVPYVYFMCKYFCZ-UHFFFAOYSA-N

SMILES

C1(C(O)=O)=C2C(C=C(C)C(CC3=CC=CC=C3)=C2)=C(CCC)C(O)=C1O

FX-11 Usage And Synthesis

Description

FX-11 is an inhibitor of lactate dehydrogenase-A (LDH-A; Ki = 8 μM). It is selective for LDH-A over GAPDH (Ki = >300 μM). FX-11 increases oxygen consumption and the production of reactive oxygen species (ROS), as well as induces cell death in P493-6 lymphoblastoid cells. In vivo, FX-11 (42 μg/animal, i.p.) reduces tumor volume in a P493-6 mouse xenograft model. It also reduces tumor weight in a BxPC-3 mouse xenograft model when administered at a dose of 2 mg/kg.

Uses

This compound is used in the synthesis of novel lactate dehydrogenase A inhibitors.This compound is suitable for lactate dehydrogenase (LDH) related research.