ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Angiogenesis > Syk inhibitors > PRT062607 (Hydrochloride)
PRT062607 (Hydrochloride)
PRT062607 (Hydrochloride) Basic information
- Product Name:
- PRT062607 (Hydrochloride)
- Synonyms:
-
- PRT062607 (Hydrochloride)
- PRT062607 (P505-15, BIIB057) HCl
- P505-15 hydrochloride
- CS-995
- BIIB057 HCl
- 4-((4-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride
- P505-15; PRT2607; PRT-2607; PRT 2607; PRT-062607; PRT 062607; P505-15; BIIB057
- 2-[[(1R,2S)-2-AMinocyclohexyl]aMino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]aMino]-5-pyriMidinecarboxaMide Hydrochloride
- CAS:
- 1370261-97-4
- MF:
- C19H24ClN9O
- MW:
- 429.90656
- Product Categories:
-
- Inhibitors
- Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 1370261-97-4.mol
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PRT062607 (Hydrochloride) Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- ≥21.5 mg/mL in DMSO; insoluble in EtOH; ≥83.2 mg/mL in H2O with gentle warming
- form
- solid
- color
- Light yellow to khaki
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PRT062607 (Hydrochloride) Usage And Synthesis
Uses
PRT062607 (Hydrochloride)acts as a novel spleen tyrosine kinase (syk) inhibitors used in the treatment of leukemia.
in vivo
PRT062607 Hydrochloride produced dose-dependent anti-inflammatory activity in two rodent models of rheumatoid arthritis. PRT062607 Hydrochloride (15, 30 mg/kg; po; bid; 5 d) causes SYK inhibition in mice and prevents BCR-induced splenomegaly in mice[1].
PRT062607 Hydrochloride (15 mg/kg; po ; bid; 5 d) SYK inhibition in mice prevents Ramos tumor formation in mouse xenograft models[1].
PRT062607 Hydrochloride (10-20 mg/kg; po; bid, ) prevents BCR mediated splenomegaly and significantly inhibited NHL tumor growth in xenograft models[2].
| Animal Model: | anti-IgD Stimulated Mouse Inflammation Model[1] |
| Dosage: | 10 mg/kg, 15 mg/kg, 20 mg/kg |
| Administration: | po; bid for 5 days |
| Result: | Suppressed mouse B-cell activation following stimulation with this anti-IgD. |
| Animal Model: | Ramos Tumor Xenograft Model in NOD/SCID mice[1] |
| Dosage: | 15 mg/kg, 30 mg/kg |
| Administration: | po; bid; terminated when tumor weights began reaching approximately 1.5 mg, at which time tumors were excised and weighed. |
| Result: | Protected mouse from Ramos tumor growth in vivo. |
target
Syk
IC 50
Lck: 249 nM (IC50, [2]); PAK5: 166 nM (IC50, [2])
PRT062607 (Hydrochloride)Supplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Jinan Trio PharmaTech Co., Ltd.
- Tel
- 0531-88811783
- sales@trio-pharmatech.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Shanghai Hope Chem Co., Ltd.，
- Tel
- +21-18501659228 18501659228
- info@hope-chem.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com